Search results for "anabolic steroid"

Androgenic-anabolic steroid effects on serum thyroid, pituitary and steroid hormones in athletes.

1987

Endocrine responses in seven power athletes were investigated during a 12 week strength training period, when the athletes were taking high doses of androgenic-anabolic steroids, and during the 13 weeks following drug withdrawal. During the use of steroids significant decreases (P less than 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P less than 0.001). In relation to the changes in the thyroid function parameters measured, we suggest that the primary target of androgen action was TBG biosynthesis. In five of…

Anabolic steroid abuse and dependence: psychiatric effects in adolescents and young adults

2009

Anabolic steroid abuse and dependence: risk factors of the use of drug and psychoactive substances

2009

Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues

2008

Predictive quantitative structure-activity relationship (QSAR) models of anabolic and androgenic activities for the testosterone and dihydrotestosterone steroid analogues were obtained by means of multiple linear regression using quantum and physicochemical molecular descriptors (MD) as well as a genetic algorithm for the selection of the best subset of variables. Quantitative models found for describing the anabolic (androgenic) activity are significant from a statistical point of view: R2 of 0.84 (0.72 and 0.70). A leave-one-out cross-validation procedure revealed that the regression models had a fairly good predictability [q2 of 0.80 (0.60 and 0.59)]. In addition, other QSAR models were …

Quantitative Structure–Activity Relationship of the 4,5α-Dihydrotestosterone Steroid Family

2006

Predictive Quantitative Structure - Activity Relationship (QSAR) models of Anabolic/ Androgenic (A/A) activities for the 4,5a-dihydrotestosterone steroid family were obtained by means of multilinear regression using quantum and physicochemical Molecular Descriptors (MDs) as well as a genetic algorithm for the selection of the best subset of MDs. MDs included in our QSAR models allow the structural interpretation of the biological process, evidencing the main role of the shape of molecules, hydrophobicity, and electronic properties. Attempts were made to include lipophilicity (octanol-water partition coefficient) as well as electronic (lowest unoccupied molecular orbital properties and dipol…

Left ventricular hypertrophy or storage disease? the incremental value of speckle tracking strain bull's-eye

2017

Left ventricular hypertrophy (LVH) develops in response to a variety of physical, genetic, and biochemical stimuli and represents the early stage of ventricular remodeling. In patients with LVH, subclinical left ventricular (LV) dysfunction despite normal ejection fraction (EF) may be present before the onset of symptoms, which portends a dismal prognosis. Strain measurement with two-dimensional speckle tracking echocardiography (STE) represents a highly reproducible and accurate alternative to LVEF determination. The present review focuses on current available evidence that supports the incremental value of STE in the diagnostic and prognostic workup of LVH. When assessing the components o…

El consum recreatiu d'esteroides anabolitzants entre els joves valencians

2012

The present study tries to measure the phenomenon of recreational consumption of anabolic steroids amongst youngsters from the city of Valencia by means of the application of qualitative methodology conducted through interviews. The sample was composed by nineteen young men aged between 21 and 34 years, that were selected from fitness centers using the snowball sampling technique. Individuals under use and abuse of anabolic steroids present patterns of consumption similar to other substances of abuse: low risk perception, repeated use and dose increase, as well as the lack of information among them. Therefore, after transcending the sports field, the consumption of anabolic steroids should …

Esteroide anabolizanteak. Goi mailako kirol alorretik gimnasioetara

2013

El presente estudio pretende caracterizar sociológicamente el consumidor recreativo de esteroides anabolizantes en tierras valencianas. La investigación se desarrolla así a partir de la aplicación de una metodología explícitamente cualitativa y la puesta en práctica de la técnica de la entrevista semiestructurada. El perfil sociológico del consumidor recreativo de esteroides anabolizantes se caracteriza por un bajo nivel de estudios, cierta inestabilidad laboral vinculada a menudo con el mundo del ocio nocturno y de la seguridad tanto privada como pública, problemas familiares, gusto por las discotecas y la playa, y frecuentes rupturas en sus relaciones de pareja, entre otros aspectos. Se c…

Ver�nderungen an Proteinen der Leber und des Blutes bei experimenteller Lebercirrhose und nach Behandlung mit Decortin und einem anabolen Steroid

1963

SEXUALHORMONE-BINDING GLOBULINE (SHBG) AND FREE TESTOSTERONE (FTE) IN PATIENTS WITH ULLRICH TURNLR SYNDROME(UTS) RECEIVING OXANDROLONE

1993

Our investigation showed that the concentration of SHBG decreased in healthy girls and boys at increased FIE concentrations. It was therefore the aim of the present study to examine the effects of anabolic steroid oxandrolone in SHBG and FTE concentrations in patients with Turner's syndrome. The normal dose to promote growth in patients wilh UTS is 0,1 mg/kg/BW. Our patients received a very low dose of 1,25 mg oxandrolone/doy. We analysed 21 sera of UTS patients. The determination of SHBG concentrations was performed with the IRMA (Famos diagnostics, Oulunsala, Finnland), the concentration of FTE was determined with the RIA (Immunchem.Corporation, Carson, USA). In 7 untreated UIS patients w…